Intracranial stress performs a key function in normal-tension glaucoma


A world crew of researchers led by means of Lithuanian scientists supply further proof that intracranial stress performs a very powerful function in normal-tension glaucoma, which accounts for as much as 50 in line with cent of all glaucoma instances. A contemporary scientific learn about demonstrates that low intracranial stress correlates with impaired affected person visibility, particularly within the nasal zone.

Glaucoma, one of the crucial main reasons of blindness for other folks over the age of 60, is brought about by means of optic nerve injury. Frequently, greater stress throughout the eye (known as intraocular stress or IOP) is detected in glaucoma sufferers. Alternatively, no longer all other folks with ocular high blood pressure expand glaucoma. Additionally, glaucoma can expand in instances of standard IOP. A so-called usual stress glaucoma (NTG) occurrence amongst sufferers within the international inhabitants levels from 30 to 90 in line with cent in line with other research.

Recent medication has how one can deal with increased eye stress and to gradual and even prevent the wear to the optic nerve. Alternatively, those strategies don’t paintings relating to usual stress glaucoma. There’s a rising consciousness a few of the clinical group, that glaucoma is a situation brought about by means of two pressures – throughout the eye and the cranium.”

Arminas Ragauskas, Professor, Kaunas College of Era (KTU), Lithuania

Ragauskas, the Head of the Well being Telematics Science Institute at KTU, is the inventor of the non-invasive intracranial stress size generation, used within the learn about described underneath.

He is going on to give an explanation for that anatomically, the optic nerve is attached to the mind, and is surrounded by means of the cerebrospinal fluid. Each intracranial stress (ICT), which is stress inside of our cranium, measured within the cerebrospinal fluid, and intraocular stress (IOP) can have an effect on the situation of the optic nerve. Lately, researchers have targeted at the steadiness between the 2 pressures, i.e. translaminar stress distinction (TPD) and its connection to glaucoma construction.

A scientific learn about published imaginable hyperlinks between mind stress and glaucoma

80 early-stage usual stress glaucoma (NTG) sufferers have been enrolled in a contemporary learn about carried out by means of researchers from Lithuanian, Israeli and American universities. The topics have been decided on from the 300 NTG sufferers referred to the Eye Medical institution on the Lithuanian College of Well being Sciences between January and October 2018.

A number of measurements together with intraocular (IOP), intracranial pressures (ICP) and field of vision perimetry have been recorded all through the learn about. The translaminar stress distinction (TPD) used to be calculated in line with the formulation TPD = IOP – ICP. The field of vision used to be divided into 5 zones: nasal, temporal, peripheral, central and paracentral.

The learn about published a number of statistically important correlations between intracranial stress, TPD and field of vision adjustments. The upper the TPD, the extra important damages to the affected person’s field of vision have been registered. Essentially the most important field of vision losses befell within the nasal zone.

“Visual view loss approach just one factor – an individual is turning into blind. That is why it’s so necessary to know the reasons of this situation and to opposite it. We’re all conscious about the dire consequence,” says Prof Ragauskas.
Researchers conclude that upper TPD might be estimated as a possibility issue for the adverse construction of standard stress glaucoma. As translaminar stress distinction is calculated by means of subtracting ICP from IOP, the decrease the intracranial stress measure, the upper the TPD. Thus, in normal-tension glaucoma, reduced intracranial stress is a imaginable possibility issue.

Era invented in Lithuania used within the learn about

“The concept mind stress is said to the field of vision isn’t new. A number of years in the past, we carried out a sequence of experiments learning the hyperlinks between field of vision and intracranial stress, the usage of the non-invasive generation advanced right here, at KTU. Within the meetings that adopted, I noticed how our new concept used to be met with pleasure by means of the world group of ophthalmologists,” says Prof Ragauskas.

Intracranial stress’s correlation with glaucoma opens new avenues for clinical execs to investigate the explanation and imaginable remedy of this pathology. Additionally, in recent times, proof supporting this speculation poured in from science teams operating around the globe. Prof Ragauskas says that his analysis has, without delay and not directly, contributed to the rising pool of knowledge at the matter.

Within the above-described learn about, the intracranial stress size used to be received by means of a two-depth Transcranial Doppler (Vittamed UAB, Lithuania) advanced by means of Prof Ragauskas’ crew on the Kaunas College of Era labs. In contrast to the standard intracranial stress measuring process, which comes to the drilling of a small-sized hollow into the affected person’s cranium, Prof Ragauskas’ invention permits measuring mind stress non-invasively during the eye the usage of ultrasound. More than a few commercial programs of the discovery have been patented in the United States and Europe.

“We aren’t competing with invasive strategies, however heading in opposition to a completely new path. In this day and age, I see that ophthalmology is the sector the place our generation is wanted maximum, and we’re the usage of it for analysis functions. Alternatively, we’re continuously creating our invention and feature lately patented a few new programs, which could be utilized in different contexts the place measuring intracranial stress is an important. For instance, in long-term house missions,” says KTU professor Ragauskas.


Magazine reference:

Stoskuviene, A., et al. (2023) The Courting between Intracranial Force and Visible Box Zones in Standard-Stress Glaucoma Sufferers. Diagnostics.

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